Cancer and Cardiology
400 Oser Avenue, Suite 1600, Hauppauge NY 11788-3619 USA
Orders: (631) 299-0024, Office: (631) 231-7269, Fax: (631) 299-0166, E-mail: billing.central@novapublishers.com
Cover

Endometrial Cancer: Risk Factors, Management and Prognosis

Author: Simone Ferrero, M.D., Ph.D.
University of Genoa, Italy

Series: Cancer Etiology, Diagnosis and Treatments

Publication Date: 2018

Book Description:
Endometrial cancer is the most common gynecological cancer and the sixth cause of cancer in developed countries. The findings that EC is a heterogeneous group of tumors with distinct risk factors and histopathological features, together with our improved understanding of its molecular mechanism has paved the way to the investigation of new surgical and medical therapies. The aim of this book is to give a complete overview on risk factors, pre-operative methods and management of endometrial cancer. The authors hope that this book will be a useful tool for any health provider involved in gynecological cancer care.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53613-887-0
ISBN: 978-1-53613-888-7

Price: $195.00
Price: $195.00


Cover

Horizons in Cancer Research. Volume 69

Editor: Hiroto S. Watanabe

Series: Horizons in Cancer Research

Publication Date: 2018

Book Description:
Horizons in Cancer Research. Volume 69 opens with a discussion on hypothetical mechanisms of the induction of NKreg cells in cancer and possible approaches to their abrogation, suggesting that for profound understanding of the problem of NKregs in the context of future target cancer immunotherapy, extensive clinical observations of NKreg cells should be carried out. Afterwards, the authors focus on the cell surface molecules in adult T-cell leukemia/lymphoma (ATL) cells, the function of matricellular proteins, particularly OPN, and their potential as targets for ATL immunotherapy. Later, the book demonstrates dual distinct functional roles of widespread cancerous immunoglobulins among cancer cells for the potential applications of RP215 in therapeutic treatments of many human cancers. RP215-linked chimeric antigen receptor (CAR)-T cell therapy technology has been applied in anti-cancer treatments through a series of CAR construction and validations by cytotoxic cell killing and cytokine activity release assays. Next, the authors present a new approach to describing, analyzing and understanding the process of dying in cancer patients based on the assumption that there are four tracks along which dying proceeds: the track focused on the medical-diagnostic aspects of the disease, the track referring to the physical aspects of the disease, the track defined by the psychological aspects of the disease and the track describing the coping- determined aspects of dying. In a separate study, examples of cases using a flexible, inflatable multi-channel applicator for the treatment of primary and recurrent gynecologic cancer, as well as treatment with Syed interstitial brachytherapy are presented. The examples are intended to emphasize the different characteristics of patient’s anatomy and tumors that guide the selection of a particular applicator and brachytherapy technique. Afterwards, the role of emodin in cancer prevention is discussed. Emodin possesses a broad spectrum of pharmacological, anticancer, anti-inflammatory, antioxidant and antimicrobial activities.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53613-296-0
ISBN: 978-1-53613-297-7

Price: $250.00
Price: $250.00


Cover

Bladder Cancer: Research Advances and Clinical Challenges

Editor: Ja Hyeon Ku, M.D., Ph.D.
Department of Urology, Seoul National University Hospital, Yongon Dong, Jongno Ku, Seoul, Korea

Series: Cancer Etiology, Diagnosis and Treatments

Publication Date: 2018

Book Description:
Bladder cancer is the fifth most common cancer with an estimated 60,490 new cases and 12,240 deaths expected for 2017 in the US alone. The diagnosis and treatment of bladder cancer in the current era is in the midst of a revolution. Recent research has focused on the evaluation of genetic markers to provide diagnostic and prognostic information in bladder cancer. In recent years, systemic therapies using a variety of immunotherapeutic strategies have evolved for the treatment of urothelial carcinoma.
Bladder Cancer: Research Advances and Clinical Challenges is a textbook on bladder cancer written by leading world experts in the field. This new book presents the latest research in this field. It has ten chapters that discuss a wide variety of the most important topics, including: cancer stem cells; molecular biomarkers; cancer detection and monitoring; clinical prognostication; immune checkpoint inhibitors; etc. It will equally be appreciated by urologists as well as scientists. The editor hopes that this book will offer the most contemporary and useful information for specialists involved in bladder cancer.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53613-354-7
ISBN: 978-1-53613-353-0

Price: $195.00
Price: $195.00


Cover

Heart Failure: What a Non-Heart Failure Specialist Needs to Know

Editor: Amin Yehya, M.D.
Advanced Heart Failure and Heart Transplant Cardiologist, Atlanta, Georgia

Series: Cardiology Research and Clinical Developments

Publication Date: 2018

Book Description:
Approaches to and therapy for many cardiovascular disorders have changed greatly over the past several decades, but perhaps none have changed so greatly as the understanding of and therapy for heart failure. Advances have occurred in the understanding of the varying physiology for this clinical syndrome, including pharmacologic therapy, device therapy, and therapy for truly advanced stages of the syndrome. Future developments may well involve gene or stem cell therapy. Clinical trials continue to define the roles of newer approaches. Clearly, this highly prevalent syndrome and the evolution of its clinical appreciation and treatment have become too extensive; it is a rapidly evolving subject that until now has not been adequately covered in a standard medical textbook.
Heart Failure: What a Non-Heart Failure Specialist Needs to Know has been created to reflect the growth and expansion of the clinical field of heart failure and is aimed at non-specialists (primary care physicians, ER staff, general cardiologists, trainees, etc.) who encounter these patients on a daily basis. The authors hope that this book will provide the background for practitioners to develop rational therapeutic regimens designed to alleviate symptoms and improve the quality and quantity of life for patients with heart failure.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53613-086-7
ISBN: 978-1-53613-087-4

Price: $230.00
Price: $230.00


Cover

Peripartum and Dilated Cardiomyopathies: Prevalence, Risk Factors and Treatment

Editor: Joseph Leonski

Series: Cardiology Research and Clinical Developments

Publication Date: 2018

Book Description:
In this compilation, the authors discuss peripartum cardiomyopathy (PPCM), a rare but serious form of heart failure affecting women in the last month of pregnancy or early postpartum. It is diagnosed by documented left ventricular systolic dysfunction in the absence of another demonstrable cause in a previously healthy woman. Prognosis is variable and appears to be positively related to reversal of ventricular dysfunction. Prompt diagnosis with institution of intense therapy by a multidisciplinary team is a prerequisite for improved outcome. Pharmacotherapy remains the mainstay of treatment for PPCM, and the management strategy is broadly aligned with established guidelines for cardiac failure.

Nevertheless, individually tailored therapy is often required for treatment of clinical sequelae, as well as for the management of delivery. At present, we lack the understanding to be able to effectively risk stratify patients and identify those susceptible to disease progression. As such, further research into this area is crucial in order to develop an understanding of which women are at greatest long-term risk, as well as to more effectively manage the condition. The authors also discuss idiopathic dilated cardiomyopathy (DCM), the second most frequent cause of heart failure and is associated with a survival rate of less than 50% at 10 years. The diagnosis is clinical and established by the presence of both left ventricle enlargement and systolic dysfunction. MRI has been increasingly applied to the evaluation of cardiovascular disease and has become the first-line imaging modality in the assessment of many types of congenital and acquired cardiovascular disorders; it could be used for global analysis of ventricular structure and function, myocardial mass and viability. It is nowadays the gold standard for assessing RV systolic function and is being increasingly used in this regard. Additionally, more than 40 genes have been identified as causative gene associated with hereditary DCM. A genetic diagnosis can confirm a hereditary DCM clinical diagnosis and it can help predict disease risks for family members before the onset of symptoms. Thus, finding predictors of DCM is of great significance as this may help doctors take precautions as soon as possible and is beneficial for long-term outcomes.

Binding: Softcover
Binding: e-Book

ISBN: 978-1-53613-753-8
ISBN: 978-1-53613-754-5

Price: $82.00
Price: $82.00


Cover

Adjuvant Chemotherapy: Current Practices, Efficacy and Future Directions

Editor: Yasushi Tsuji, M.D., Ph.D.
KKR Sapporo Medical Center, Tonan Hospital, Sapporo, Hokkaido, Japan

Series: Cancer Etiology, Diagnosis and Treatments

Publication Date: 2018

Book Description:
In the age of constant knowledge via computer accessibility, the effort to write a book on adjuvant chemotherapy may seem almost futile. However, the information seen online is usually fragmented, without context, and often somewhat unreliable. This book aims to provide a handy and reliable reference to better understand both the current situation and the future directions in the field of adjuvant chemotherapy. Its ten chapters covering major cancers were written by prominent researchers with decades of experience in clinical settings as well as in related fields of research.

Owing mostly to the development of novel cancer drugs, cytotoxic agents, targeting agents and immune check point inhibitors, the prognosis of all cancers has markedly improved. On the other hand, determining the best way to use these drugs is becoming more and more complicated, and most patients after recurrence are still unlikely to be cured. Carefully planned and meticulously executed surgery, appropriate adjuvant chemotherapy and radiotherapy still play major roles in treatment, and they can significantly increase cure rates, especially in the advanced stages. This book contains a wealth of the latest international data and detailed information assist professionals in making the best possible decisions regarding specific and patient-oriented treatments.

From the general introduction to the principles of adjuvant chemotherapy in chapter one to all the details in the chapters covering specific cancers, we hope this book will inspire veterans in the field with new ideas and help to guide and educate young doctors and researchers, all towards the ultimate goal of providing better care for our patients.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53613-933-4
ISBN: 978-1-53613-934-1

Price: $230.00
Price: $230.00


Cover

A Closer Look at Cardiovascular Diseases and Risk Factors

Editor: Faris van Kilsdonk

Series: Cardiology Research and Clinical Developments

Publication Date: 2018

Book Description:
In recent decades, obesity levels have increased worldwide, thus also increasing the prevalence of morbid obesity. This type of obesity is associated with a large number of comorbidities that increase the mortality risk of the patients who suffer it. In this compilation, the authors examine treatment options for this type of population. Bariatric surgery has proven to be an effective method, generating large weight reductions and improving cardiovascular risk factors, thus increasing the life expectancy of patients who undergo it.
However, this surgery also has certain disadvantages. In recent years, several studies have also determined that performing exercise at high intensities and adding resistance training to an exercise program generates greater losses of fat mass and reductions in cardiovascular risk factors compared to traditional recommendations. Additionally, endothelial dysfunction is a well-described precursor to the development of clinically overt coronary and peripheral artery disease, and is present early in the course of the disease. It reflects not only the global atherosclerotic status, but also the degree of rigidity of the whole artery system. The measurement of endothelial function could therefore represent an additional prognostic marker of cardiovascular risk.
The authors stress the necessity to find methods that could evaluate the endothelial function in an easier and less invasive way. Following this, the authors review the relationship between cardiovascular risk factors, systemic circulatory diseases and inner ear disorders, particularly focusing on the involvement of cardiovascular factors in the pathogenesis of sudden sensorineural hearing. The inner ear may be impaired by vascular affections since it is supplied by a terminal blood flow and has a sustained metabolic activity. It has been reported that the function of labyrinthine vessels can be influenced by several local factors such as perivascular sympathetic innervation, arterial systemic blood pressure and labyrinth liquids pressure ratio, antidiuretic hormone receptors, endothelial dysfunction and ionic transport mechanisms. Next, the current evidence of obesity-related comorbidities is reviewed, along with the cardiovascular risk factor index after different bariatric approaches.
Bariatric surgery has been shown to be effective in achieving and maintaining weight change and reducing obesity-related comorbidities. Malabsorptive procedures have been associated with the greatest reduction of cardiovascular risk and the greatest improvement in obesity-related comorbidities. On the other hand, the lowest improvement is seen after restrictive procedures. In conclusion, cardiovascular diseases are the leading cause of death in both men and women. There has been steady decline in mortality from cardiovascular diseases in middle-aged men based on recent data from the National Health and Nutrition Examination Surveys, but for women this rate has remained relatively unchanged. Although there are similarities in most classic risk factors in men and women, the varying implications of these risk factors for both genders are examined.

Binding: Softcover
Binding: e-Book

ISBN: 978-1-53613-939-6
ISBN: 978-1-53613-940-2

Price: $95.00
Price: $95.00


Cover

Pancreatic Cancer

Editor: Jana Katuchova, M.D., Ph.D.
First Department of Surgery, Medical Faculty of Safarik University and University Hospital, Košice, Slovakia

Series: Cancer Etiology, Diagnosis and Treatments

Publication Date: 2018

Book Description:
Pancreatic cancer is a very aggressive carcinoma with a poor prognosis. From all options currently available for pancreatic cancer patients, surgical resection offers the only potential for a cure.
The high mortality rate of pancreatic cancer is related to the advanced stage of disease at the time of diagnosis. However, it is extraordinarily difficult to make an early diagnosis of pancreatic adenocarcinoma based on clinical signs and symptoms only. Due to the nonspecific characteristics of the early symptoms and their insidious nature, pancreatic cancer is often mistaken for other diseases. Moreover, the pancreas is a relatively inaccessible organ for physical examination.
This book reviews important literature about pancreatic cancer. Chapter One of this book describes the etiology and pathology of pancreatic cancer. Chapter Two presents up-to-date possibilities in the diagnosis of pancreatic cancer. Chapter Three describes the surgical treatment of pancreatic cancer and postoperative surgical complications in detail. This chapter describes the standard and extended lymphadenectomy performed during radical pancreatic resection for pancreatic cancer. Chapter Four describes borderline pancreatic cancer and brings new knowledge concerning vascular reconstruction during radical surgical resection. Chapter Five discusses systemic therapy for patients with pancreatic cancer.

Binding: Softcover
Binding: e-Book

ISBN: 978-1-53613-982-2
ISBN: 978-1-53613-983-9

Price: $95.00
Price: $95.00


Cover

Horizons in Cancer Research. Volume 70

Editor: Hiroto S. Watanabe

Series: Horizons in Cancer Research

Publication Date: 2018

Book Description:
Progression of colorectal cancer (CRC) is a main cause of its morbidity and mortality. CRC progression is characterized by increased growth of the primary carcinoma as well as lymphatic and haematogenic spread. The microenvironment of primary or circulating and disseminated tumor cells seems to be essential in all steps of the metastatic process of CRC. Therefore, the authors suggest that cancer-associated cellular stroma evolving from the extracellular matrix should be crucially integrated with CRC diagnosis, staging and treatment.

Following this, a short review focuses on the immunohistochemical findings and the molecular signaling pathways during the development from chronic inflammation to Kaposi’s sarcoma formation. Kaposi’s sarcoma is a multifocal neoplasm characterized by deregulated neoangiogenesis, proliferation of spindle cells with infiltrated inflammatory cells and erythrocytes in the skin and visceral organs.

The papillary thyroid carcinoma from tall cells (tall cell variant, TCV) was first described by Hawk and Hazard in 1976. 162 such cases were published in the world literature prior to 2000. This is a rare tumor with a frequency of 1-2 cases per million people in Europe and the US. Taking into account the histological pattern, immunophenotype and the results of molecular genetic research, additional differential diagnostic criteria for papillary thyroid cancer from tall cells with transformation into anaplastic carcinoma have been proposed.

Cervical cancer is mainly caused by infection with high-risk types of human papillomavirus (HPV), especially type 16. In this collection, the authors present a study which reveals that HPV16E6 protein induces COX-2 gene and protein expression through PI3K/Akt signaling pathway in association with the increase of PGE2-EP4 receptor leading to promote carcinogenesis.

False positive and false negative diagnoses in focal carcinomas of the prostate represents one of the most common and significant problems in daily practice. Thus, the authors conclude with a summary of the criteria of greatest value to establish the diagnosis of carcinoma when only some neoplastic glands are found. These focal adenocarcinomas have been termed limited, minimal, minimal volume carcinoma and microcarcinomas. Although most are unique, they may occasionally be found in other sites on the same biopsy, in subsequent biopsies, or in prostatectomy products.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53614-186-3
ISBN: 978-1-53614-187-0

Price: $250.00
Price: $250.00


Cover

Horizons in World Cardiovascular Research. Volume 15

Editor: Eleanor H. Bennington

Series: Horizons in World Cardiovascular Research

Publication Date: 2018

Book Description:
In this compilation, the authors present and discuss various aspects of arrhythmias in endurance competitive and leisure-time sportsmen including master athletes based on their extensive experience and international literature. The value of heart rate monitors for evaluating exercise intensity and for diagnosis of arrhythmias is discussed and standard procedure for dealing with suspected arrhythmias useful both for athletes, their coaches or doctors is proposed.
Next, the authors focus on recent literature data related to the role of endothelial nitric oxide and inducible nitric oxide in physiological and pathophysiological conditions. Nitric oxide is a free radical which, in reactions with various molecules, causes multiple biological effects. It is exceptionally regulated and extends to almost every cell type and function within circulation.
Extracranial carotid artery stenosis is a major cause of stroke and is treated with either carotid endarterectomy (CEA) or percutaneous transluminal angioplasty (PTA) and carotid artery stenting (CAS). In this collection, several types of imaging study have been used to identify complications related to in-stent restenosis, including Doppler ultrasound, computed tomography angiography, digital subtraction angiography, magnetic resonance angiography, intravascular ultrasound, and optical coherence tomography.
The authors go on to discuss some recent randomized studies that compared different d rug-eluting balloon catheters (DEB) with drug-eluting stents (DES) used to treat BMS- in-stent restenosis or DES- in-stent restenosis, and the long-term clinical results of those studies. Evidence from controlled clinical studies has suggested that DES and drug-eluting balloon catheters (DEB) provide the best clinical and angiographic results in the treatment of ISR.
Following this, the dynamics of the conformation changes in the subdomains of the NC1 hexamer under the influence of sound frequencies distressing them was studied in gelatin (film) and collagen (cardiac aorta/veins endothelium) obtained from pork, using the gravitation mass spectroscopy method (GMS).
Continuing, most coronary events are caused by significant stenoses or vulnerable plaques. Recent studies have shown that significant stenoses and vulnerable plaques often coexist. The basic concept that underlies these entities is increased plaque volume. Additionally, recent evidence shows that coronary calcium score and fractional flow reserve are the most accurate methods to assess increased plaque volume, and therefore, have high prognostic value.
The main goal of the subsequent study is the application of an immunohistochemistry technique in order to diagnose myocardial ischemia in early stages with a better confidence rate. Sudden cardiac death cases were selected and their findings were qualitatively and quantitatively assessed. The study focuses on the evolution and location of fibronectin in the ischemic cardiomyocytes during process of infarction and remodeling of cardiac scars.
Lastly, the authors investigate the incidence of very late in-stent restenosis and risk factors for very late target lesion revascularization (TLR) in patients with sirolimus-eluting stent (SES). Very late SES-TLR was associated with history of hemodialysis and previous PCI with SES for ISR lesion.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53614-184-9
ISBN: 978-1-53614-185-6

Price: $250.00
Price: $250.00


Cover

Acute Myeloid Leukaemia (AML): Symptoms, Diagnosis and Treatment

Editor: Irvin Mendez

Series: Cancer Etiology, Diagnosis and Treatments

Publication Date: 2018

Book Description:
Acute myeloid leukemia is the most common adult acute leukemia, but its etiology in individual patients is poorly understood. An increased risk of acute myeloid leukemia may be inherited (through congenital hematologic diseases and syndromes or germline disorders) or be acquired due to a lifetime of exposure to environmental or chemical agents, or genotoxic stress. In this collection, the authors explore risk factors for acute myeloid leukemia, newer epidemiologic studies on the connections between these risks and clinical phenotypes and outcomes of the disease.

The subsequent chapter evaluates different prognostic factors and stratifications of risk that have been published in an attempt to assess the influence of acute myeloid leukemia progression on the overall survival of myelodysplastic syndromes patients, evaluating them in a population-based registry.

Many acute myeloid leukemia patients cannot tolerate standard chemotherapy due to its high toxicity. A milder therapy for acute myeloid leukemia has long been sought after, and until now the only successful clinical application has been all-trans-retinoic acid-based therapy for just one subtype of acute myeloid leukemia, acute promyelocytic leukaemia. The concluding chapter aims to address other therapeutic candidates.

Binding: Softcover
Binding: e-Book

ISBN: 978-1-53614-345-4
ISBN: 978-1-53614-346-1

Price: $82.00
Price: $82.00


Cover

Research on New Generation Tumor Markers

Editor: Yildiz Dincer, Ph.D.
Istanbul University- Cerrahpasa, Cerrahpasa Medical Faculty, Department of Medical Biochemistry, Istanbul, Turkey

Series: Cancer Etiology, Diagnosis and Treatments

Publication Date: 2018

Book Description:
Many cancers are associated with the abnormal production of some molecules which can be measured in plasma/urine or can be detected on the surface of resected tumor tissue. These molecules are known as tumor markers. The potential uses of tumor markers are screening in the general population, differential diagnoses of symptomatic patients, clinical staging of cancer, estimating tumor volume, indicating prognosis, monitoring treatment and detecting recurrences. In order to obtain maximum clinical benefit, a tumor marker should have some characteristics. A tumor marker should be tissue-specific. The plasma level of the tumor marker should be in proportion to the size and activity of the tumor. A tumor marker should be present in plasma at a detectable level, even though tumor size is very small. A tumor marker should reflect the altered tumor characteristic as a response to therapy.
Unfortunately, currently used tumor markers do not meet all of these criteria. A majority of them are present in normal, benign and tumor tissues, and unfortunately, they are not specific enough to be used for cancer screening in the general population. In addition, conventional tumor markers are poor in reflecting altered tumor behavior in response to anticancer therapy. They are of most value during follow-up appointments. Recent developments in molecular biology have led to the identification of numerous new tumor biomarkers. Firstly, the detection of DNA and RNA freely circulating in blood has provided a new perspective for the early diagnosis of cancer, patient follow-up, and assessment of therapy efficacy. Circulating free nucleic acids can originate from both malignant and non-malignant tissues. Discrimination of tumor cells is based on the presence of tumor-specific genetic and epigenetic alterations. This circulating nucleic acid-based approach is termed a “liquid biopsy.” Due to its non-invasive and repeatable features, liquid biopsy is a promising tool for cancer patients. It is particularly helpful in cancers where solid tissue biopsies are not feasible, and in the metastatic patients when multiple distinct tumor masses are simultaneously present.
As another advantage, liquid biopsy shows the current tumor dynamics during anticancer therapy and drug sensitivities that conventional examinations fail to reflect. Secondly, self-renewable stem cells have the potential to cause cancer. If stem cells are genetically or epienetically changed, their differentiation potential becomes impaired and their proliferative capacity becomes uncontrolled. Current anticancer therapies mostly fail to eradicate cancer stem cells and instead favor expansion of the cancer stem cell pool and/or select for resistant stem cells. Thirdly, microRNAs, non-coding RNAs and transfer RNA fragments found in the bloodstream are candidate markers for the diagnosis and prognosis of different types of cancer. This book provides an overview of these new molecular tumor markers.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53614-367-6
ISBN: 978-1-53614-368-3

Price: $230.00
Price: $230.00


Cover

Clinical Oncoproteomics: Proteome-Based Personalized Anti-Cancer Therapy

Editor: Andrey S. Bryukhovetskiy, M.D., Ph.D.
Federal Research Center for Specialized Types of Medical Assistance and Medical Technologies of FMBA of Russia, Moscow, Russia

Series: Cancer Etiology, Diagnosis and Treatments

Publication Date: 2018

Book Description:
This monograph is dedicated to the issues of clinical oncoproteomics, its role and place in contemporary medicine in general, and in particular, oncology. This book reviews various academic viewpoints on the informational component and value of the data of clinical oncoproteomics for the diagnostics and treatment of malignant tumors using cellular, genomic and post-genomic technologies.
The monograph summarizes modern concepts of carcinogenesis and describes the author’s informational theory of cancer onset. The book presents theoretical, methodological and technical aspects of the innovative medical technology of the personalized proteome-based cell therapy of neoplasms. The author describes his own experience in mapping, proteomic and transcriptomic profiling of the postnatal regional progenitors and cancer stem cells of cancer patients, and the methods of bioinformational processing and mathematical modeling of the results. This book also demonstrates mathematical instruments that are used to detect the regulatory targets of the proliferative and reproductive functions of cancer stem cells in tumors and production of the targeted individually tailored anti-cancer proteome-based cell products. The mechanisms, limitations and future of these technologies are examined relying on the evidence of the clinical proteomics.
This book is intended for a broad range of specialists, including clinical doctors of different specializations, such as oncologists, surgeons, neurologists, neurosurgeons, intensivists, immunologists, biochemists, molecular biologists, geneticians, professors and students of medical colleges, as well as specialists working with the issues of cell therapy and personalized medicine.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53614-477-2
ISBN: 978-1-53614-478-9

Price: $230.00
Price: $230.00


Cover

Stress (Takotsubo) Cardiomyopathy: A Crosstalk between the Brain and Heart

Editors: Wei-Ting Chang, M.D.
Department of Cardiology, Chi-Mei Medical Center, Tainan, Taiwan
Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan
Wen-Lieng Yu
Department of Cardiology, Chi-Mei Medical Center, Tainan, Taiwan
Chon-Seng Hong, M.D.
Department of Cardiology, Chi-Mei Medical Center, Tainan, Taiwan
Chia-Te Liao, M.D.
Department of Cardiology, Chi-Mei Medical Center, Tainan, Taiwan
Jinn-Rung Kuo, M.D., Ph.D.
Department of Neurosurgery, Chi-Mei Medical Center, Tainan, Taiwan
Yen-Wen Liu
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University, Tainan, Taiwan

Series: Cardiology Research and Clinical Developments

Publication Date: 2018

Book Description:
Stress cardiomyopathy, also called Takotsubo cardiomyopathy or apical ballooning syndrome, is defined as acute left ventricular dysfunction associated with high stimulation of endogenous or exogenous catecholamine in a critically ill individual. The detailed mechanisms underlying the association between this autonomic storm and myocardial toxicity are comprehensively discussed in this book. According to the diagnostic criteria released by the American Heart Association, the diagnosis of this reversible cardiomyopathy requires: 1) Transient left ventricular wall motion abnormalities involving the apical and/or midventricular myocardial segments with wall motion abnormalities extending beyond a single epicardial coronary artery distribution; 2) the absence of obstructive epicardial coronary artery disease that could be responsible for the observed wall motion abnormality; 3) ECG abnormalities, such as transient ST-segment elevation and/or diffused T wave inversion associated with a slight troponin elevation; and 4) the lack of proven pheochromocytoma and myocarditis.
However, the detailed mechanisms through which the autonomic nervous systems regulate the heart and the manner in which their impairment caused adverse effects on cardiovascular function have not yet been well described. Also, increasing evidences indicated that the long term cardiovascular or neurologic impact of stress cardiomyopathy may not be as benign and we thought. Also, there is limited evidence regarding the management. At least recent clinical researches explored whether specific factors explain specific patient susceptibilities to the disease and should be directed towards early identification and stratification at risk. The purpose of this book is to provide an up-to-date review of the clinical presentation of stress cardiomyopathy, discuss possible causal mechanisms, and highlight the recent development of managements.
This issue of stress cardiomyopathy comprehensively discussed the crosstalk between the brain and the heart. Experts review the most updated literature regarding clinical profile, imaging modalities, management and infectious or neurologic stress induced cardiomyopathy. The latest information will help medical practitioners in the diagnosis and management of this condition.

Binding: Softcover
Binding: e-Book

ISBN: 978-1-53613-355-4
ISBN: 978-1-53613-356-1

Price: $82.00
Price: $82.00


Cover

Laryngeal Cancer: Risk Factors, Symptoms and Treatment

Editors: Andrea De Vito, M.D., Ph.D.
Head and Neck Department, ENT Unit and Oral Surgery, Morgagni-Pierantoni Hospital, AUSL of Romagna, Forlì, Italy
Sheng-Po Hao, M.D.
Department of Otolaryngology Head and Neck Surgery, Comprehensive Oral Cancer Center, Shin Kong Wu Ho-Su Memorial Hospital, Taiwan
Claudio Vicini, M.D.
Head and Neck Department, ENT Unit and Oral Surgery, Morgagni-Pierantoni Hospital, AUSL of Romagna, Forlì Italy

Series: Cancer Etiology, Diagnosis and Treatments

Publication Date: 2018

Book Description:
Laryngeal cancer is one of the most common cancers of the head and neck. The best diagnostic approach is provided by performing a full endoscopic evaluation, appropriate imaging and biopsy. Therapy can thereafter be tailored to pathology, stage of disease, and then individualized.

The multidisciplinary tumor board represents an essential requirement in oncologic diagnosis and treatment, often introducing clinical challenges which force us to overcome our personal opinion in solving a case in a specific manner.

This book represents a collection of our retrospective analysis of the local weekly tumor board which includes the otorhinolaryngologist, oncologist, radiotherapist, pathologist, radiologist and speech pathologist. We have also included reviews from national and international opinion leaders in the field of laryngeal cancer.

The book is organized into three sections: basic science, diagnostic work-up and treatment, with the aim of providing a concise, up-to-date, and appropriate overview of the anatomy, risk factors, conventional and newest diagnostic management, open partial laryngectomies, laser CO2 transoral laryngeal microsurgery, and conventional and robotic total laryngectomy.

The authors hope to procure a practical guideline for medical students, general practitioners, ENT specialists and, moreover, medical specialists whose roles are to provide the best up-to-date diagnostic and therapeutic management to patients with laryngeal cancer.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53613-450-6
ISBN: 978-1-53613-451-3

Price: $160.00
Price: $160.00


Cover

Burkitt Lymphoma: Updates in Etiology, Diagnosis, Molecular Genetics and Treatment Options

Editors: Ling Zhang, M.D. and Lubomir Sokol, M.D., Ph.D.
University of South Florida, Tampa, FL, US

Series: Cancer Etiology, Diagnosis and Treatments

Publication Date: 2018

Book Description:
Burkitt lymphoma (BL) is a lymphoid neoplasm originating from a mature, follicular center B-cell that is phenotypically positive for CD10, BCL-6, LOM2, and HGAL, with a hallmark genetic translocation involving the MYC gene (at 8q24) and its partner – either immunoglobulin heavy chain (14q) or light chain (kappa at 2q and lambda at 22q) – and a very aggressive clinical nature. BL can be divided into three clinical subcategories: Endemic, sporadic and HIV/AIDS/immunodeficiency with prevalence in children, adolescents and young adults. Clinical manifestations could slightly be variable upon its clinical subcategories; however, they share certain similar features, e.g., fast growing mass, frequent extranodal presentation, are associated with EBV infection, and sensitive to tumor reduction therapy with a high risk of tumor lysis syndrome and uric acid nephropathy. It is important to differentiate BL from other aggressive types of B-cell lymphomas as with intensive, short-term chemotherapy, e.g., hyper-CVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone, methotrexate, and cytarabine).

Additionally, CNS prophylaxis BL showed a much better clinical response. Nearly all types of BL lack or dimly express BCL-2, differentiating it from other mimickers. A diagnostic challenging variant of BL – an MYC-negative harboring 11q abnormalities, namely “Burkitt-like lymphoma with an 11q aberration” – has been recently proposed. Novel next generation sequencing and gene expression profiling has brought about new insights into BL. TCF3(E2A), a transcription factor involving the regulation of lymphoid cell survival and proliferation, its negative regulator known as ID3, and the downstream gene CCND3 were also frequently mutated in cases of BL. The characterization of molecular biology and the genetic profile of BL leads to the future of personalized medicine and targeted therapy. This book focuses on the epidemiology, etiology, clinical presentations/staging, differential diagnoses, MYC-driven pathogenesis and therapeutic options concerning BL. These updates in BL and associated EBV- or MYC-positive diseases will benefit trainees, physicians and basic scientists who engage in the diagnosis, treatment, and novel drug development for this disease.

Binding: Hardcover
Binding: e-Book

ISBN: 978-1-53614-164-1
ISBN: 978-1-53614-165-8

Price: $160.00
Price: $160.00